Ko te Hydroxypropyl methylcellulose, e mohiotia ana ko HPMC, he rongoa rongoa me te taapiri kai.Na te pai o te whakarewatanga, te kaha here me nga taonga hanga kiriata, kua whakamahia nuitia i roto i te umanga rongoa.Kei te whakamahia hoki te HPMC i roto i te umanga kai hei whakakaha, whakaehunga me te whakapumau.Ko te ma o te HPMC he mea tino nui i roto i nga umanga rongoa me te kai na te mea e pa ana ki te pai me te haumaru o te hua.Ka matapakihia e tenei tuhinga te whakatau o te pokekore HPMC me ona tikanga.
He aha nga HPMC?
Ko te Hydroxypropylmethylcellulose (HPMC) he etera cellulose i ahu mai i te methylcellulose.Ko te taumaha o te ngota ngota he 10,000 ki te 1,000,000 Daltons, he paura ma, he ma ranei, he hongi me te reka.Ko te HPMC he ngawari ki te wairewa i roto i te wai, me te wairewa ano ki etahi whakarewa pararopi penei i te waihano, butanol, me te chloroform.Kei a ia etahi ahuatanga motuhake penei i te pupuri wai, te matotoru me te kaha here, e pai ana mo te ahumahi rongoa me te kai.
Te whakatau i te pokekore HPMC
Ko te maatanga o te HPMC ka whakawhirinaki ki etahi ahuatanga penei i te tohu whakakapinga (DS), te makuku me te ihirangi pungarehu.Ko te DS te tohu i te maha o nga roopu hydroxyl i whakakapihia e nga roopu hydroxypropyl i roto i te ngota ngota cellulose.Ko te nui o te whakakapinga ka piki ake te whakarewatanga o te HPMC me te whakapai ake i te kaha o te hanga kiriata.He rereke, he iti te whakakapinga ka iti te wairewa me te ngoikore o nga ahuatanga hanga kiriata.
Tikanga Whakatau Maama HPMC
He maha nga tikanga mo te whakatau i te parakore o te HPMC, tae atu ki te titration waikawa-turanga, tātaritanga huānga, chromatography wai mahi teitei (HPLC), me te spectroscopy infrared (IR).Anei nga korero mo ia tikanga:
titration waikawa-papa
Ko te tikanga i runga i te tauhohenga whakaheke i waenga i nga roopu waikawa me nga roopu taketake i roto i te HPMC.Tuatahi, ka rewa te HPMC ki te whakarewa, ka taapirihia he rōrahi o te waikawa, te wairewa turanga ranei o te kukū e mohiotia ana.I mahia te titration kia tae ra ano te pH ki te ira kore.Mai i te nui o te waikawa, te turanga ranei i pau, ka taea te tatau te tohu whakakapinga.
Te tātari huānga
Ko te tātari huānga ka ine i te ōrau o ia huānga kei roto i te tauira, tae atu ki te waro, te hauwai, me te hāora.Ko te tohu whakakapinga ka taea te tatau mai i te nui o ia huānga kei roto i te tauira HPMC.
Koromatography Wai Teitei (HPLC)
He tikanga wetewete te HPLC e wehe ana i nga waahanga o te ranunga i runga i o raatau taunekeneke ki nga waahanga tuuturu me nga waahanga pūkoro.I roto i te HPMC, ka taea te tatau te tohu whakakapinga ma te ine i te ōwehenga o te hydroxypropyl ki nga roopu methyl i roto i te tauira.
Hiringa Hinengaro (IR)
Ko te hiranga infrared he tikanga wetewete e ine ana i te whakaurunga, te tuku ranei o te iraruke infrared i tetahi tauira.He rereke nga tihi absorption HPMC mo te hydroxyl, methyl me te hydroxypropyl, ka taea te whakamahi hei whakatau i te tohu o te whakakapi.
Ko te maa o te HPMC he mea nui i roto i nga mahi rongoa me nga umanga kai, a ko tana whakatau he mea nui ki te whakarite i te haumaru me te kaha o te hua whakamutunga.He maha nga tikanga e waatea ana hei whakatau i te pokekore o te HPMC, tae atu ki te titration waikawa-turanga, tātaritanga huānga, HPLC, me te IR.Kei ia tikanga nga painga me nga ngoikoretanga ka taea te kowhiri i runga i nga whakaritenga motuhake o te tono.Hei pupuri i te pokekore o te HPMC, me penapena ki tetahi wahi maroke, hauhautanga kei tawhiti atu i te ra me etahi atu poke.
Wā tuku: Akuhata-25-2023