Ko te HPMC e kiia ana ko te hydroxypropyl methylcellulose.
Ko te hua HPMC te kowhiri i te miro cellulose tino parakore hei rauemi mata, ka hangaia ma te whakaeera motuhake i raro i nga tikanga kawakore.Ka oti te mahi katoa i raro i nga tikanga GMP me te aro turuki aunoa, kaore he kai kaha penei i nga whekau kararehe me te hinu.
Ngā āhuatanga HPMC:
Ko te hua HPMC he katote cellulose ether, ko te ahua he paura ma, he kakara kore, he wairewa i roto i te wai me te nuinga o nga whakarewa pararopi polar (pēnei i te dichloroethane) me te wahanga tika o te waihano/wai, te waipiro propyl/wai, me etahi atu. mahi, tino marama me te mahi pumau.Kei a HPMC nga ahuatanga o te waiariki waiariki, ka werahia te wairewa wai hua ki te hanga i te rerenga rea, ka rewa i muri i te whakamahana, he rereke nga whakaritenga o te pāmahana rea hua.Ka huri te riipene me te viscosity, te iti o te viscosity, te nui ake o te whakarewatanga, he rereke nga whakaritenga o te HPMC ki ona ahuatanga, kaore te HPMC i te wai e pa ki te uara PH.Te rahi o te matūriki: 100 te reeti whakawhiti mata he nui ake i te 100%.Kiato rahi: 0.25-0.70g/ (te nuinga o te 0.5g/), te taumaha motuhake 1.26-1.31.Te wera o te tae: 190-200 ℃, te wera waro: 280-300 ℃.Te mānukanuka mata: 42-56dyn/cm i roto i te 2% wairewa wai.Na te pikinga o te ihirangi methoxyl, ka heke te tohu o te reera, ka piki te wairewa wai, ka piki hoki te mahi o te mata.Kei a HPMC nga ahuatanga o te whakamaroke, te tote, te iti o te pungarehu, te pumau o te PH, te pupuri wai, te pumau o te ahua, te hanga kiriata pai me te nui o te aukati ki te whaariki, te mararatanga me te whakakotahitanga.
Nga tono HPMC:
1. Papa paninga: HPMC whakamahia rite rauemi paninga kiriata i roto i te faaineineraa totoka, Ka taea e hanga uaua, maeneene me te ataahua kiriata, te kukū whakamahi o 2% -8%.I muri i te paninga, ka piki ake te pumau o te kaihoko ki te marama, te wera me te makuku;Te reka me te hongi, ngawari ki te tango, me te poaka HPMC, te whakamarumaru o te ra, nga whakahinuhinu me etahi atu pai o te hototahitanga o nga rawa.Ko te paninga noa: te wai, te 30-80% ranei te waihano hei whakakore i te HPMC, me te 3-6% te otinga, me te taapiri i nga kai awhina (penei: te pāmahana oneone -80, te hinu castor, PEG400, talc, me etahi atu).
2. Ko te paparanga wehenga whakakikorua-wairewa-a-roto: i runga i te mata o nga papa me nga granules, ka whakamahia tuatahi te whakakikorua HPMC hei papa o raro, ka whakakikoruatia ki te paparanga o te rauemi enteric-soluble HPMCP.Ka taea e te kiriata HPMC te whakapai ake i te pumau o te kaihoko paninga enteric-wairewa i roto i te rokiroki.
3. Whakaritenga tuku totika: ma te whakamahi i te HPMC hei kaihoko pore-inducing me te whakawhirinaki ki te ethyl cellulose hei taonga angaahi, ka taea te hanga i nga papa mahi roa-roa.
4. mātotoru mātotoru me te colloid tiaki whakapiri me te kanohi makaka: HPMC mō te mātanga thickening whakamahia nuitia kukū o 0.45-1%.
5. Adhesive: HPMC rite te herenga kukū whānui o 2% -5%, whakamahia ki te whakapai ake i te pūmautanga o te whakapiri hydrophobic, nuitia whakamahia kukū o 0.5-1.5%.
6. Te kaihoko whakaroa, te kaihoko tuku me te kaihoko whakatara.Kaituku whakatārewatanga: ko te 0.5-1.5%.
7. Kai: HPMC rite mātanga mātotoru tāpiri ki te momo o te inu, hua miraka, condiments, kai kai tōtika, rite mātanga thickening, here, emulsifier, māngai whakatārewatanga, stabilizer, kaihoko pupuri wai, excifer, etc.
8. Whakamahia i roto i Paku rite adhesives, emulsifiers, āpiha hanga kiriata, etc.
Wā tuku: Hānuere-14-2022